Handshake Drugs was originally performed by Wilco.

Handshake Drugs has been played by Umphrey's McGee 2 times, across 1 show(s).
It was played at 0.04% of Umphrey's McGee shows.
It was last played 2019-08-18, which was 384 show(s) ago.
There have been 384 show(s) since the live debut.
Since its debut, "Handshake Drugs" has been played, on average, once every 384 show(s).